【摘 要】
：
Alpha7 nicotinic acetylcholine receptor (αT nAChR), a ligand-gated ion channel, is extensively expressed in various tumor cells and involved in regulation of cell proliferation, angiogenesis, apoptosi
【机 构】
：
State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking Univer
【出 处】
：
2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
论文部分内容阅读
Alpha7 nicotinic acetylcholine receptor (αT nAChR), a ligand-gated ion channel, is extensively expressed in various tumor cells and involved in regulation of cell proliferation, angiogenesis, apoptosis, migration, invasion and secretion, making it to be a new valuable molecular target for the therapy of cancers.α-Conotoxin ImI, a disulfide-rich toxin purified from the venom of Conus imperialis, blocks homomeric alpha 7 nicotinic receptors with high apparent affinity.
其他文献
Pingyangmycin hydrochloride (PYM) is an effective sclerosing agent to treat vascularmalformations(VM), but can easily diffuse from the injection site, which will reduce the therapeutic effect of PYM a
Obejective There is a large amount of evidence demonstrating that many tumors have high low density lipoprotein (LDL) requirements and express relatively high levels of LDL receptors on their membrane
The combination of doxorubicin (DOX) with sorafenib (SOR) has been proved to be an effective strategy to enhance anti-hepatocellular carcinoma (HCC) efficiency However, varied in vivo pharmacokinetic
Purpose: Here, we report the safety, tumor accumulation and potential of polyethylene glycol-grafted graphene oxide (pGO) as a multimodal nanocarrier of photosensitizers and synergistic anticancer age
Multidrug resistance (MDR) is one of the major reasons for the failure of chemotherapy.In this study, a series of pluronic unimers was conjugated to polyamidoamine (PAMAM) dendrimers.Do xo rub if in (
Objective: To enhance the effective diagnosis of tumor by magnetic resonance imaging (MRI), aptamer-targeted liposomes combined with gadolinium (Gd) were designed and constructed as a novel MRI contra
Peptide dendritic polymer based nanoparticles have presented significant potential to be a candidate for drug/gene delivery system owing to the features of dendritic polymers, such as great biocompati
BACKGROUND: In the treatment of human non-small-cell lung cancer(NSCLC), intravenous administration makes drugs accumulate not only in the lungs but also in other organs and may undergo degradation in
Asthma is a common disease of pediatrics that can be treated with tulobuterol patch, avoiding inconvenience of injecting including pains and repeated administration as well as of oral route such as di
Nucleic acid-based methods for controlling gene expression have had a considerable impact on research involving gene pathways and function.In addition, gene therapies are potentially powerful candidat