Magnesium and its alloys as a biodegradable materials are being more and more peoples attention for for biomedical applications but the biggest challenge is the proper corrosion control. In our work, the zirconium ions integrated an ultrathin bisphosphonate film, 1-hydroxyethylidene- 1,1-diphosphonic acid (HEDP) was deposited on magnesium,which is supposed to enhanced corrosion controlling and osteo-compatible. The zirconium ions integrated the small molecules HEDP coated on magnesium not only bio-safe, but also form a film significantly enhanced corrosion-controlling of magnesiums. In an in situ chemical sequence, the HEDP molecules were covalently surface-immobilized on the alkaline pretreated Mg and then spontaneously deposited by participation in a chelating reaction with Zr ions. An organ metallic-like compound layer was thus formed, which was ascertained to be within the nanoscale and complied well with the substrate.By electrochemical corrosion and in vitro immersion degradation investigations demonstrated that the zirconium ions integrated HEDP film on magnesium shows significantly improve cossion resistance of magnesium-substrate compared to untrated samples. In addition Zr Ion-Integrated HEDP coating performed osteo-compatible to enhanced bioactivity of bonelike apatite precipitation and osteoblast cells adhesion and proliferation. Our the zirconium ions integrated HEDP film modified Mg may bode well for application in biomedical applications.