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  5. Myocardium-targeted transplantation of PHD2 shRNA-modified mesenchymal stem cells by ultrasound-targ

Myocardium-targeted transplantation of PHD2 shRNA-modified mesenchymal stem cells by ultrasound-targ

来源 :中国超声医学工程学会第十四届全国超声心动图学术会议 | 被引量 : 0次 | 上传用户：liruimei12345
【摘 要】
：
Objective:Mesenchymal stem cell therapy has been proposed as a promising therapy for acute myocardial infarction(AMI).However,some studies showed little effect of MSCs on AMI.One of the limitations ar
【作 者】
：
Li Zhang Zhengxing Sun Mingxing Xie 
【机 构】
：
Department of Ultrasound,Union Hospital,Tongji Medical College,Huazhong University of Science and Te
【出 处】
：
中国超声医学工程学会第十四届全国超声心动图学术会议
【发表日期】
：
2018年3期
【关键词】
：
Ultrasound targeted microbubble destruction Marrow stem cell Acute myocardial in 
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　　Objective:Mesenchymal stem cell therapy has been proposed as a promising therapy for acute myocardial infarction(AMI).However,some studies showed little effect of MSCs on AMI.One of the limitations are low homing efficiency of MSCs at the site of injury.We hypothesis that Ultrasound targeted microbubble destruction(UTMD)technique combined with PHD2 shRNA-modified MSCs enhances the homing efficiency of transplanted stem cells and improves cardiac function in myocardial infarction of rats.
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