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目的 屋尘螨是国际公认的最强的致敏原 ,国外已有丹麦、美国等发达国家饲养成功 ,产品已经商品化 ,我国尚无屋尘螨饲养成功的报道 ,因而从 1990年起我科试行人工饲养 ,于 1996年底获得初步成功 ,收集到小批量的纯屋尘螨。方法 摸索屋尘螨在人工饲养下的生态条件及能使屋尘螨繁殖生长的饲料配方 ,将人工饲养的屋尘螨经专家鉴定确定为屋尘螨后 ,收集制成干粉 ,浸泡制成纯屋尘螨抗原浸液供临床测试。结果 用人工饲养的屋尘螨抗原 ,在变态反应的门诊病人中与粉尘螨浸液同时作皮内试验 ,共检测 110 3名各类变态反应疾病的病人 ,结果屋尘螨的皮试总阳性率为 6 4 .4 6 % ,粉尘螨的总阳性率为 5 8.2 9% ,P <0 .0 0 5。检测病人血清中特异性IgE ,屋尘螨的总强度亦比粉尘螨高。结论 屋尘螨在我国已人工饲养成功 ,这对提高我国的变态反应疾病的诊疗水平有重要的意义 ,经我们的测试屋尘螨抗原是目前已知的抗原中致敏性最强的致敏原
Purpose House dust mite is the strongest allergen internationally recognized, foreign countries such as Denmark, the United States and other developed countries have successfully reared, the product has been commercialized, there is no reported success of house dust mite feeding, so since 1990, our department Preliminary trial of artificial breeding, obtained initial success at the end of 1996, collected small quantities of pure house dust mites. Methods To explore the ecological conditions of house dust mite under artificial feeding and the feed formula that can make the house dust mite reproduce and grow. After the house dust mite was identified as house dust mite by experts, it was collected and made into dry powder, soaked into pure House dust mite antigen infusion for clinical testing. The results of artificial dust house dust mite antigens, allergic clinic patients and dust mite dipping at the same time for intradermal test, a total of 1103 patients with various types of allergic diseases were detected, the results of skin test house dust mite positive The total positive rate of dust mite was 5 8.29%, P <0.05. Detection of patient serum specific IgE, house dust mites than the total strength of dust mites higher. Conclusion The house dust mite has been successfully reared in our country, which is of great significance to improve the diagnosis and treatment of allergic diseases in our country. The dust mite antigens of our house are the most sensitive allergens in the known antigens original