【摘 要】
：
Iminosugars or azasugars,which exhibit effective inhibition against carbohydrate-processing enzymes,have attracted great interest for their potential clinical applications as anti-HIV,anti-diabetic,an
【机 构】
：
Key Laboratory of Chemical Biology of Hebei Province,College of Chemistry and Environmental Science,
【出 处】
：
全国药物化学学术会议暨第四届中英药物化学学术会议
论文部分内容阅读
Iminosugars or azasugars,which exhibit effective inhibition against carbohydrate-processing enzymes,have attracted great interest for their potential clinical applications as anti-HIV,anti-diabetic,and anti-cancer agents and immunomodulators in past decades1.The promising activities and the potential applications in clinic trial of the azasugars inspired us to explore its innovative analogs to develop novel iminosugar-based drugs2.Recently,by using microwave-assisted one-pot tandem Staudinger/aza-Wittig/condensation reaction,we have conveniently synthesized a series of novel bi/tricyclic azasugars fused thiazolidin-4-one and thiazinan-4-one3.
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