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  5. Direct inhibition of calmodulin inhibitor,CGS 9343B on voltage-dependent K+Channels expressed in art

Direct inhibition of calmodulin inhibitor,CGS 9343B on voltage-dependent K+Channels expressed in art

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：xingke198621
【摘 要】
：
We investigated the effects of the calmodulin inhibitor CGS 9343B on voltage-dependent K+(Kv)channels using whole-cell patch clamp technique in freshly isolated rabbit coronary arterial smooth muscle
【作 者】
：
Hye Won Kim Hongliang Li Won Sun Park 
【机 构】
：
Department of Physiology,Kangwon National University School of Medicine,Chuncheon,200-701,South Kore
【出 处】
：
2016年国际生理学学术大会
【发表日期】
：
2016年6期
【关键词】
：
CGS 9343B Calmodulin Coronary artery Voltage-dependent K+channel 
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　　We investigated the effects of the calmodulin inhibitor CGS 9343B on voltage-dependent K+(Kv)channels using whole-cell patch clamp technique in freshly isolated rabbit coronary arterial smooth muscle cells.CGS 9343B inhibited Kv currents in a concentration-dependent manner,with a half-maximal inhibitory concentration(IC50)value of 0.81 μM.
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