Autophagy is an essential component of host innate and adaptive immunity.Viruses have developed diverse strategies for evading or utilizing autophagy for survival.The response of the autophagy pathways to virus invasion is poorly documented.Here, we report on the induction of autophagy initiated by the pathogen receptor heat shock protein 90 alpha (HSP90AA1) via the AKT-MTOR (mechanistic target of rapamycin)-dependent pathway.Transmission electron microscopy and confocal microscopy revealed that intracellular autolysosomes packaged avibimavirus particles.