【摘 要】
：
Dihydropyridine receptor(DHPR) and Ryanodine receptor(RyR),two ion channel proteins in muscle cells,play a key role in excitation-contraction coupling in muscle
【机 构】
：
DepartmentofBiophysics,PekingUniversityHealthScienceCentreandCentreforProteinScience,PekingUniversit
【出 处】
：
第四届全国冷冻电子显微学与结构生物学专题研讨会
论文部分内容阅读
Dihydropyridine receptor(DHPR) and Ryanodine receptor(RyR),two ion channel proteins in muscle cells,play a key role in excitation-contraction coupling in muscle cells.In skeletal muscle,contraction initiates from the depolarization of surface membrane of muscle cells,which activates the DHPR/L-type Ca2+channel in surface membrane;the activation of DHPR leads to conformational changes of DHPR,which are communicated to the RyR in sarcoplasmic reticulum membrane through physical coupling,inducing conformational changes of RyR and leading to the opening of RyR channel and release of Ca2+from sarcoplasmic reticulum.The released Ca2+ions then induce muscle contraction.To unveil the molecular mechanism of excitation-contraction coupling,structural information is essential.In this lecture,I will present our recent structural work on DHPR and RyR,which provides structural insights into the architecture,ion selectivity,activation mechanism of DHPR and RyR,and mechanism of excitation-contraction coupling.
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