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O-GlcNAcylation,a dynamic process that is catalyzed by O-GlcNAc transferase(OGT)and O-GlcNAcase(OGA),represents a signal transduction pathway that plays critical roles in a variety of cellular processes.The process plays an important role in skeletal muscle growth and physiological functions,and inappropriate O-GlcNAc glycosylation could damage the formation of muscle fibers,and induce muscle atrophy.