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Calcium carbonate(CaCO3) is one of the basic inorganic materials, which has been widely used as pharmaceutical excipient.Amorphous calcium carbonate is attracted much attention because of its wonderful properties—porous structure, biocompatibility, high drug loading capacity and high surface area.CaCO3 microparticles(MPs) with different sizes were synthesized by a simple precipitation method,mixing equal volumes of CaCl2 and Na2CO3 solutions.