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5. Discovery of Novel PTP1B Inhibitors as Antihyperglycemic Agents through Pharmacophore-Oriented Scaff

Discovery of Novel PTP1B Inhibitors as Antihyperglycemic Agents through Pharmacophore-Oriented Scaff

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：wwvicky

【摘 要】

：

Protein tyrosine phosphatase(PTP) 1B is a potential therapeutic target for type 2 diabetes.Due to the positively charged nature of its catalytic site,PTP1B is an intractable target for drug discovery

【作 者】

：

Xin Du Junzheng Liu Jinying Tian Fei Ye Zhiyan Xiao 

【机 构】

：

Institute of MateriaMedica,Chinese Academy of Medical Sciences

【出 处】

：

第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会

【发表日期】

：

2012年8期

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论文部分内容阅读

　　Protein tyrosine phosphatase(PTP) 1B is a potential therapeutic target for type 2 diabetes.Due to the positively charged nature of its catalytic site,PTP1B is an intractable target for drug discovery and the achievement of in vivo activity is one of the major bottlenecks.

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