论文部分内容阅读
Purpose:Toprospectivelyevaluatethesafetyandefficacyofradiofrequency(RF)ablationoflungneoplasmswithdiameterofless than30mm. Methods:Writteninformedconsentwasobtainedinthisprospectivestudythatwasapprovedbythelocalethicscommittee. Fourtypatients(24menand16women;agerange,35–78years;meanage,58years)with52unresectablemalignantlung neoplasmswereenrolledin.RFablationwasperformedintumorsbyusingcomputedtomographic(CT)guidance,eachwitha diameteroflessthan30mm(meandeviation,14mm).Follow-upCTscanswereobtainedwithin48hoursaftertreatmentandat 2,6and12monthsthereaftertoevaluatetreatmentoutcomeandcomplications.Lungspirometrymeasurementswereobtained beforeand2monthsafterRFablation. Results:Fifty-twolesionsweretreatedandsixty-fivesuccessfulradiofrequencyablationtreatmentswereperformed,eachlasting 15minutes.Thecomplicationsoccuredintheperiproceduralperiodwere5casesofminorpneumothoraxand4casesofsputum cruentum.Therewere35lesionsofreducedsize,15lesionsofstabilizedlesionsize,and2lesionsofincreasedsizeonthefollowup Contrast-enhancedCTimagesat6-month.Contrast-enhancedCTperformedat12-monthfollow-upshowedunchangedsize of10lesions,reducedsizeof38lesionsandincreasedsizeof4lesions.Therewasnomodificationofrespiratoryfunctionwas foundbetweenthespirometrymeasurementsbeforethetreatmentand2monthsafter(P<0.05). Conclusion:RFablationisasafeandeffectivemethodtotreatunresectablemalignantlungneoplasmswithdiameteroflessthan 30mm.Largerstudiesarenecessarytofullyevaluateitspotentialcombinationwithothertreatmenttechniques.