【摘 要】
：
[目的]探讨免疫组织化学(IHC)提示HER-2++的浸润性乳腺癌中临床病理因素与荧光原位杂交(FISH)检测HER-2基因扩增状态之间的关系.[方法]182例免疫组织化学提示HER-2++的浸润性乳腺癌的石蜡标本进行荧光原位杂交检测,对FISH结果采用UC FDA标准进行相关评价.[结果]该入组人群中位年龄为48岁(29～78岁),63例标本经FISH检测评价为HER-2基因扩增；相对于HER-
【机 构】
：
浙江省肿瘤医院放疗科 浙江省肿瘤医院病理科
【出 处】
：
2014华东胸部肿瘤论坛暨第七届浙江省胸部肿瘤论坛
论文部分内容阅读
[目的]探讨免疫组织化学(IHC)提示HER-2++的浸润性乳腺癌中临床病理因素与荧光原位杂交(FISH)检测HER-2基因扩增状态之间的关系.[方法]182例免疫组织化学提示HER-2++的浸润性乳腺癌的石蜡标本进行荧光原位杂交检测,对FISH结果采用UC FDA标准进行相关评价.[结果]该入组人群中位年龄为48岁(29～78岁),63例标本经FISH检测评价为HER-2基因扩增；相对于HER-2无扩增的其余标本中,HER-2基因扩增组存在以下现象：ER阴性率更高(58.8％ versus 25.2％,P=0.000),PR阴性率更高(57.1％ versus 26.3％,P＜0.001),p53阴性率更高negative (44.8％ versus 29.8％,P=0.048),Ki67指数在HER-2基因扩增组远高于HER-2基因无扩增组(P=0.006).使用ER、PR、p53及Ki67等指数组成危险因素比值,危险因素比值与HER-2基因状态有着明显的统计学相关性(X2=30.41,P=0.000).[结论]使用ER、PR、p53及Ki67等指数组成危险因素比值能够很好地预测IHC HER-2++标本上HER-2基因的最终状态.
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