Functional annotation of lncRNAs based on lncRNA-Histone modification association network

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户:kingworsebest
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Background: Increasing evidences demonstrate that long non-coding RNAs (lncRNAs) play many important roles in a variety of biological processes.Despite of limited knowledge of functional IncRNAs, it should be clear that lncRNAs possess the ability of multilevel regulation of gene expression through complicated molecular mechanisms, which remain to be elucidated.
其他文献
Background: Allosteric drugs, taking an action-at-a-distance mechanism to achieve regulations on the protein functions, have several advantages over conventional orthosteric drugs, including diverse r
Background: Influenza A(H3N2) virus causes continuing epidemics in the human society since its emergence in 1968, due to its ability to change its antigenicity frequently through rapid mutations and t
Background: Nucleus acid-protein interaction plays important role in various biological processes.Therefore, identify the residues in proteins that bind to DNA or RNA can significantly understand the
Background: Human immunodeficiency virus type 1 (HIV-1), which is the pathogen of acquired immunodeficiency syndrome (AIDS), causes about 2 millions death every year.Based on the carboxy-terminal hept
Background: Allostery is a rapid and efficient way in many biological processes to regulate protein functions, where binding of an effector at the allosteric site alters the activity and function at a
Background: The PB1-F2 is the 11th protein of influenza A virus, encoded by the +1 alternate open reading frame (ORF) in the PB1 gene and previously reported to be a virulence factor that could contri
Background: The recognition of protein functional sites would further enhance our understanding of protein function and some relevant biological processes.Currently, due to the problems of insufficien
Background: MicroRNAs (miRNAs) play important roles in post-transcription by repressing translation or causing mRNA degradation.A single miRNA may be involved in the expression regulation of a large n
Background: Accumulating evidence demonstrates that complex diseases may arise from cooperative effects of multiple dysfunctional miRNAs.Thus, identifying abnormal functions cooperatively regulated by
Background: Deep sequencing with new computational approaches for assembling transcriptome has identified tens of thousands of large intergenic transcripts across different tissues and cell types.Thes