Synthesis and Biological Evaluation of Molecular Imaging Probe and Photodynamic Therapy Photosensiti

来源 :The First Asian Conference on Porphyrins, Phthalocyanines an | 被引量 : 0次 | 上传用户:liwei20062
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  The efficiency of cancer treatment drugs significantly relies on their tissue and intracellular localization.Two types of tumor targeting approach have been realized so far,namely positive or passive targeting.Herein,due to their excellent biological stability and good coordination ability with various metal ions,macrocyclic polyamine and phthalocyanine were chosen to construct molecular imaging probe and photosensitizer for targeted cancer treatment.
其他文献
Single molecular nanoparticles(SMNPs)integrating imaging and therapeutic capabilities exhibit unparalleled advantages in cancer theranostics,ranging from excellent biocompatibility,high stability,prol
超分子组装可以使发色团形成J-聚集结构并产生吸收红移,这为制备近红外材料提供了一种可能的新途径。由于传统超分子组装体的吸收红移较小(通常小于30 nm),如何有效提高材料性能、实现大于100 nm的红移成为亟待解决的关键问题之一。本工作使用酞菁—短肽缀合物作为组装单元,首次制备了基于酞菁的超分子近红外材料。
Control of self-assembly is significant to the preparation of supramolecular materials and illustration of diversities in either natural or artificial systems.Supra-amphiphiles have remarkable advanta
本文采用高温固相法合成了Bi2SrTa2O9层状材料,并用二次离子交换法制备了CoTMPyP/SrTa2O7纳米复合材料。利用一系列的表征方法,如XRD、SEM、TEM、IR、UV-vis等研究了材料的空间结构和形貌特征。并通过循环伏安法和微分脉冲伏安法探究了CoTMPyP/SrTa2O7复合材料对亚硝酸钠的电催化氧化性能。
本文通过传统的固相烧结法制备层状主体材料LiNbWO6,利用硝酸对其进行酸化,得到质子化产物HNbWO6,并用四丁基氢氧化铵对HNbWO6进行剥离处理,得到带有负电荷的[NbWO6]-纳米片.通过静电力作用,[NbWO6]-纳米片与钴卟啉(CoTMPyP)阳离子可自组装成新型纳米复合材料CoTMPyP/NbWO6.采用XRD、SEM、TEM、IR、UV-vis等表征手段,研究材料的结构和形貌.此外
光功能材料是光的转化和利用的物质基础,在信息、光电器件、绿色能源等众多领域有重要用途。光功能材料的核心问题在于其波长和激发态性质的调控,这两种性质直接决定了材料和器件的性能。光功能配合物因其良好的氧化还原活性和组装能力,分子结构易修饰,及丰富的轨道吸收和强旋轨耦合等特点,在分子电子学、近红外电致变色、信息存储及电致发光器件等诸多方面应用广泛。
在光动力治疗的过程中,提高光敏剂对肿瘤细胞的选择性是一个非常重要的课题.本文设计合成了RGD环肽(RGDyK)与锌酞菁(ZnPc)相连的新型光敏剂ZnPc-RGD.该种水溶性材料不仅对癌细胞和肿瘤血管表面过表达的αvβ3 整合素具有高选择性,而且其生物稳定性也随之增加.
Photodynamic antimicrobial chemotherapy is an attractive modality to treat the microbial infections.Antimicrobial peptides have the ability to target and kill the pathogenic microorganism specifically
会议
We have designed and synthesized a series of hybrid nanostructures based rich graphdiyne by self-assembly and self-organizing technique.The process and mechanism of growing hybrid nanostructures have