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Purpose:To explore the preparation method and characters of targeting folate-conjugated doxorubicin-loaded magnetic albumin nanospheres (FA-DOX-BSANPs)and its antitumor effect on oral squamous cell carcinoma(OSCC) in vitro and vivo.Mehhods: The FA-DOX-BSANPs,which have encapsulated iron oxide nanoparticles, was prepared by desolvation-crosslinking method.