The Synthesis of Phosphylated Tyrosine Adducts

来源 :第十三届中国国际多肽大会 | 被引量 : 0次 | 上传用户：haludahuaidan

【摘要】

：

　　Organophosphate(OP)esters including nerve agents and pesticides[1] which can inhibit the activity of acetylcholinesterase[2] can cause serious harm to human

【作者】

：

Fengjuan Sun Hongmei Wang Daoming Sun Runli Gao Dongyuan Zhao Chengxin Pei

【机构】

：

StateKeyLaboratoryofNBCProtectionforCivilian,POBox1044,ChangpingDistrict,Beijing,102205,P.R.China

【出处】

：

第十三届中国国际多肽大会

【发表日期】

：

2014年6期

【关键词】

：

Nerve agent Pesticide Tyrosine adducts

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　　Organophosphate(OP)esters including nerve agents and pesticides[1] which can inhibit the activity of acetylcholinesterase[2] can cause serious harm to human.OP phosphylate a tyrosine residue on albumin in human body to form the phosphylated tyrosine adducts.These adducts may offer relatively long-lived biological markers of OP exposure.Sensitive methods for the detection of these adducts have been developed using liquid chromatography-mass spectrometry.In this paper,five phosphylated tyrosine adducts were synthesized with Solid-Phase Synthesis.

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The Synthesis of Phosphylated Tyrosine Adducts

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