Cardioprotective effects of epoxyeicosatrienoic acids (EETs) toward acute myocardial ischemia-reperfusion injury have been recognized;however, the precise mechanism(s) are still largely unknown.Our study investigates the protective effects of EETs by inhibiting soluble epoxide hydrolase (sEH), the enzyme responsible for EET metabolism, following surgical occlusion of left anterior descending artery (LAD) of the heart.Age matched 2 month old sEH null (KO) and littermate wild-type (WT) mice were utilized in the study, as well C57B1/6 mice which were administered an sEH inhibitor, trans-4-[4-(3-adamantan-1-y1-ureido)-cyclohexyloxy]-benzoic acid (tAUCB;10mg/L) or vehicle in drinking water for 4 days prior and 7 days post surgery.