Assembly of Thermodynamically and Chemically Stable RNA Nanoparticles Escorting Mirna, Sirna and Dru

来源 :International Conference on Nanoscience & Technology,China 2 | 被引量 : 0次 | 上传用户：suojianpku798

【摘要】

：

【作者】

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Dan Shu Yi Shu Farzin Haque Peixuan Guo

【机构】

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Department of Pharmaceutical Sciences,University of Kentucky,Lexington,KY 40536,USA

【出处】

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International Conference on Nanoscience & Technology,China 2

【发表日期】

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2013年3期

【关键词】

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RNA nanotechnology RNA nanoparticle as drug RNA therapeutics Phi29 nanomotor pRN

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　　One of the advantages of RNA Nanotechnology is the feasibility to construct therapeutic particles carrying multiple therapeutics with defined structure and stoichiometry.Herein, we report the construction of varieties of thermodynamically and chemically stable RNA nanoparticles to carry one, two three or four siRNA,miRNA, RNA aptamer, or ribozyme using reengineered RNA fragments derived from the central domain of the motor pRNA of bacteriophage phi29 DNA packaging motor.

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Assembly of Thermodynamically and Chemically Stable RNA Nanoparticles Escorting Mirna, Sirna and Dru

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