背景：阻塞性睡眠呼吸暂停低通气综合征(Obstructive sleep apnea-hypopnea syndrome,OSAHS)是一种全身性疾病,主要表现为打鼾、呼吸暂停、夜间反复低氧血症、高碳酸血症和睡眠结构紊乱。研究认为OSAHS是心血管疾病的独立危险因素。慢性间断缺氧是OSAHS主要的病理生理基础,能够促进动脉粥样硬化形成和斑块破裂,机制尚未明确。基质金属蛋白酶(MMP)和组织蛋白酶(
Sexual arousal ensures the necessary waking state allowing the anticipation and performance of sexual activities and so is a prerequisite for reproduction.Its importance is uncontestable, but the mech
目的：酒是广泛使用的精神刺激性饮品，酒中主要成分酒精对睡眠觉醒具有重要的调节作用，但其机制不明。前期研究表明，酒精能够直接增加脑内胞外腺苷水平。本研究旨在探究腺苷系统参与酒精诱导睡眠的可能机制。
The high prevalence of sleep disturbance has been found in patients with striatum-related neurodegenerative disorders.Striatum lesions in animals exhibited a 15% reduction in wakefulness.
Introduction: The ventral tegmental area (VTA) is crucial for brain functions, such as voluntary movement, cognition, emotion, reward, and motivation.However, the role of VTA in sleep-wake regulation
OBJECTIVE To elucidate the role and neural circuits of glutamatergic parabrachial nucleus (PB) neurons in the regulation of wakefulness.METHODS A chemogenetic approach was employed to clarify the elec
Sleep is regulated by two mechanisms, the homeostatic process and the circadian rhythm.Light affects sleep and alertness by entraining the circadian clock and inducing sleep/alertness acutely,which is
目的：通过临床观察证实二白汤治疗高血压伴失眠症的有效性.方法：通过对睡眠障碍专家门诊及中医科住院90例高血压伴失眠症病例,非随机临床分为两组,治疗组46例用二白汤治疗,对照组44例服用酒石酸唑吡坦片,两组对照比较治疗的有效率、治疗前后的国际通用SPIEGEL量衰减分率情况、中医症候变化及血压的变化情况、用药后的不良反应.结果：治疗组有效率为91.3％,对照组有效率为75.0％,两组比较有显著差异性
目的 研究中青年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的血清氧化应激水平和认知状况及两者的相关性，并评估持续气道正压通气(CPAP)对血清氧化应激程度及认知功能的影响。
Background: Our purpose was to investigate the relationship between oxygen saturation (SpO2) and dynamic interstitial glucose level (IGL) in patients with obstructive sleep apnea (OSA) along with type