A novel strategy to enhance specificity of MT1-MMP-activatable fluorescent probe for tumor imaging

来源 :中国化学会第十届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：xxzzxx_100

【摘要】

：

　　The overlapping substrate specificities within the family of MMP(Matrix Metalloproteinase)enzymes which were associated with tumorigenesis,adds the potentia

【作者】

：

Shuping Xie Xiuru Ji Huining He Lu Sun

【机构】

：

TianjinKeyLaboratoryonTechnologiesEnablingDevelopmentofClinicalTherapeuticsandDiagnostics(Theranosti

【出处】

：

中国化学会第十届全国化学生物学学术会议

【发表日期】

：

2017年9期

【关键词】

：

MT1-MMP peptide substrate specificity activatable fluorescent probe

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　　The overlapping substrate specificities within the family of MMP(Matrix Metalloproteinase)enzymes which were associated with tumorigenesis,adds the potential for a substrate to be cleaved by multiple enzymes within this family,this leads to a decreasing specificity of MMP substrate-based probes.

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A novel strategy to enhance specificity of MT1-MMP-activatable fluorescent probe for tumor imaging

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