β-榄香烯衍生物的抗肿瘤活性及构效关系研究进展

来源 :2013中国药学大会暨第十三届中国药师周 | 被引量 : 0次 | 上传用户：LIUSHENGWU5

【摘要】

：

目的：综述β-榄香烯衍生物的抗肿瘤活性及构效关系的研究进展.方法：查阅β-榄香烯衍生物研究的相关文献,重点概述有活性报道的β-榄香烯衍生物的抗肿瘤活性及构效关系.结果：经对文献进行分析归纳,并结合本课题组研究工作,总结了各类衍生物的抗肿瘤活性及初步构效关系.结论：在保持β-榄香烯整个分子骨架和双键的前提下,在13、14位引入含氮、含氧基团合成的大多数β-榄香烯衍生物的体外抗肿瘤活性高于β-榄香烯,

【作者】

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徐莉英杜惠莲张美慧董金华

【机构】

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沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016 沈阳医学院附属卫校

【出处】

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2013中国药学大会暨第十三届中国药师周

【发表日期】

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2013年6期

【关键词】

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β-榄香烯衍生物抗肿瘤活性构效关系

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β-榄香烯衍生物的抗肿瘤活性及构效关系研究进展

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