Evoking picomolar binding in RNA aptamer by a single phosphorodithioate linkage

来源 :第三届中国核酸适配体学术研讨会 | 被引量 : 0次 | 上传用户:awper1985
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  RNA aptamers are synthetic oligonucleotide-based affinity molecules that utilize unique three-dimensional structures for their affinity and specificity to a target such as a protein.They hold the promise of numerous advantages over biologically produced antibodies;however,the binding affinity and specificity of RNA aptamers are often insufficient for successful implementation in diagnostic assays or as therapeutic agents.Strong binding affinity is important to improve the downstream applications.
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