【摘 要】
：
喹唑啉是药物化学中的优势骨架结构，含有喹唑啉骨架的化合物具有抗炎、抑菌、抗结核、抗糖尿病、抗HIV和抗肿瘤等多种生物活性。以邻氨基苯甲酸为起始原料，依次与甲酰胺反应闭环制备喹唑啉-4-酮，与硝酸反应制备6-硝基喹唑啉-4-酮，水合肼还原制得6-氨基喹唑啉-4-酮，再与酸酐或酰氯反应制备6-酰胺喹唑啉-4-酮，三氯氧磷氯化制备4-氯喹唑啉-6-酰胺，最后与二硒化纳反应得到二(6-酰胺喹唑啉-4-基)
【机 构】
：
鲁东大学化学与材料科学学院,烟台,264025 蚌埠医学院生物科学系,蚌埠,233030
论文部分内容阅读
喹唑啉是药物化学中的优势骨架结构，含有喹唑啉骨架的化合物具有抗炎、抑菌、抗结核、抗糖尿病、抗HIV和抗肿瘤等多种生物活性。以邻氨基苯甲酸为起始原料，依次与甲酰胺反应闭环制备喹唑啉-4-酮，与硝酸反应制备6-硝基喹唑啉-4-酮，水合肼还原制得6-氨基喹唑啉-4-酮，再与酸酐或酰氯反应制备6-酰胺喹唑啉-4-酮，三氯氧磷氯化制备4-氯喹唑啉-6-酰胺，最后与二硒化纳反应得到二(6-酰胺喹唑啉-4-基)二硒醚类化合物。各目标化合物经波谱确证其结构，体外抗癌活性测试正在进行中。
其他文献
Given a linear difference equation,there is a difference-differential Galois group that encodes the differential-algebraic dependencies among the solutions of the equation.
Recent experiments(Ouriemi & Vlahovska,2014)show intriguing surface patterns when a uniform electric field is applied to a droplet covered with colloidal particles.Depending on the particle properties
The challenge of optimal information gathering-for the purpose of inference,prediction,design,or control-pervades fields ranging from geophysics to chemical engineering and beyond.These questions can
We formulate an A-optimal experimental design criterion for infinitedimensional nonlinear Bayesian inverse problems.Our method aims to minimize the average variance of a Gaussian approximation to post
A hybrid approach for solving Laplace equation in 3-D domains is presented.It bases on a local method for the Dirichlet-Neumann(DtN)mapping of a Laplace equation by combining a deterministic boundary
In this talk,we will introduce accurate numerical methods for solving coupled nonlinear forward backward stochastic differential equations with applications in solving fully nonlinear second-order par
Nonlinear filtering problems arise in many application fields such as financial mathematics,signal processing,target tracking,and biological sciences.
The monodomain equations represent a reasonably accurate model for the electric potential of the human heart.The PDE-ODE structure of the linearized model leads to a system that is not null controllab
以水为反应介质,采用碳酸钠为缚酸剂,在微波辐射的条件下,使芳胺与σ-溴代苯乙酮反应,合成N,N-二烷基化苯胺。其中,探讨了微波功率、缚酸剂种类和缚酸剂剂量等因素对反应产率的影响。该方法具有环境友好、后处理简便、反应时间短和产率高等优点[1,2]。
蓝萼香茶菜富含具有抗肿瘤活性的贝壳杉烯型二萜类化学成分。我们从该植物中共分离鉴定40个单体化合物,其中5个为新化合物,1个是新骨架化合物。蓝萼甲素为该植物中主要成分,具有较好抗肿瘤作用。为了进一步研究该类结构抗肿瘤作用构效关系,及寻找更高活性的化合物,我们对蓝萼甲素进行了结构修饰。对分离得到的二萜类化合物及合成的衍生物用MTT法测试了四种人肿瘤细胞进行了体外抑制活性,结果表明α-亚甲基环戊酮是对映