【摘 要】
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To gain further insights into the genomic landscape of prostate cancer, we performed whole-genome sequencing and transcriptome profiling of tumor-benign pairs from 65 Chinese prostate patients.Genome
【机 构】
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Deapertmrnt of Urology, Changhai Hospital The Second Military Medical University, Shanghai, China
【出 处】
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Genome Variation in Precision Medicine(第四届《自然遗传》疾病基因组学国际研讨会)
论文部分内容阅读
To gain further insights into the genomic landscape of prostate cancer, we performed whole-genome sequencing and transcriptome profiling of tumor-benign pairs from 65 Chinese prostate patients.Genome wide somatic variations revealed associations between mutation signature, local hypermutation, and chromoplexy.Our comprehensive analysis provides details on novel genetic signatures, driver genes and altered pathways, which could enhance our understanding of the tumor heterogeneity complexity and provide potential therapeutic targets for advanced prostate cancer.
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