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Background: Many pre-miRNAs have been reported to yield two kinds of mature miRNAs, although the two products, miR-#-5p and miR-#-3p, may vary in expression levels.Arm selection and/or arm switching in miRNAs may influence miRNA expression profiles.Methods: In the present study, we mainly discussed this under three aspects: ① primary evolutionary analysis of human miRNAs;② evolutionary analysis of miRNAs from different arms across the typical vertebrates;③ expression pattern analysis of miRNAs at the miRNA/isomiR levels using public small RNA sequencing datasets.