Introduction:The latest ILCOR guidelines recommend a target compression depth of at least 5cm and rate of > 100/minute.The aim of the study is to investigate Asian first rcsponders tolerance of sustaining external chest compressions (CCs) in a manikin training setting.Materials and Methods:Three cycles of chest compressions (about 6 minutes) were performed by 91 volunteers on a CPR manikin (The Resusci Anne(R) QCPR(R)).The performance data collected included compression depth (CD) and compression rates (CR).Results:A total of 91 medical school students from China participated in the study.The participants heart rate (HR),systolic blood pressure (SBP), diastolic blood pressure (DBP) before and after participation were documented.The participants body mass index (BMI), their right upper arm circumference (AC) and fatigue severity score (FSS)also were documented.The mean depth of compression (male vs female) over 3 cycles were 49.27±7.39mm vs 43.04±8.15mm, 46.8±9.28mm vs 40.02±8.10mm, and 45.55±9.41 mm vs 38.46±8.67mm.The change of the participants of SP, DP, HR,FSS after CPR between different gender was not significant(p>0.05).CD was significantly associated with gender and BMI.However, there is no statistical significance between the three cycles CDR and right upper of AC.Conclusion:In conclusion, Asian first responders tolerance of sustaining external chest compression may be below current recommended guidelines and thus require frequent rotations for chest compression during resuscitation.