【摘 要】
：
To minimize the toxic insults of DNA double strand break (DSB), organisms have developed three efficient repair pathways: Homologous Recombination (HR), Non
【机 构】
：
CollegeofLifeSciences,ZhejiangUniversity,866YuHangTangRoad,Hangzhou310058
论文部分内容阅读
To minimize the toxic insults of DNA double strand break (DSB), organisms have developed three efficient repair pathways: Homologous Recombination (HR), Non-Homologous End Joining (NHEJ), Single-Strand Annealing (SSA).A central part of DNA damage response is activation of tumour repressor p53 resulting in cell cycle arrest, DNA damage repair, apoptosis, or senescense to guard the genome stability.Surprisingly p53 inhibits DNA DSB repair.There are various p53 isoforms in vivo.However, information on the functions of the p53 isoforms in DNA damage repair is lacking.Our previous studies showed that an N-terminal truncated p53, △113p53/△133p53 is a p53 target gene, which is strongly induced by DNA damage signals.In this study, we found that △113p53 is only induced by ionizing irradiation, but not by UV irradiation and heat shock.
其他文献
Magnesium (Mg2+) is an abundant divalent cation in a living cell and plays fundamental role in massive physiological and biochemical processes.However, the
Sumoylation is involved in extensive cellular processes in Eukaryotes.In planta, SUMO is implicated in flowering-time control, responses to biotic and abiot
Cloning and function research of FT (flowering locus T)-like homologs in cotton havent been reported.In the present study, an FT-Like homolog was isolated f
In this study, the "Nuda" phenotype in Yunnan Nuda Rice, a glabrous cultivar that constitutes approximately 20% of rice germplasms in Yunnan, China, was fou
The control of floral organ identity by homeotic MADS-box genes is well established in eudicots.However grasses have highly specialized outer floral organs,
Transcriptional regulation, posttranscriptional regulation, and signaling pathways play crucial roles in cell differentiation.The model organism C.elegans p
Chorioallantoic branching morphogenesis is a key milestone during placental development, creating the large surface area for nutrient and gas exchange and i