Voltage-Gated Potassium Channels (Kv) are involved in proliferation and transformation in mammary epithelial cells.In previous studies, several groups have detected various potassium channels in breast cancer cells, and they assumed that potassium channels are related to the development of breast carcinoma, although the precise mechanisms are still unknown.Caveolin-1 (Cav-1) is a principal component of Caveolae membranes, acting as a marker protein for the organdie involved in cellular signaling.