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  5. Surface dual-targeting equipped nanogels intracellularly deliver cytotoxic agent to suppress highly

Surface dual-targeting equipped nanogels intracellularly deliver cytotoxic agent to suppress highly

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户：wjh_1201
【摘 要】
：
Targeted delivery of chemotherapeutic agents to desired lesion sites was a great challenge in clinical cancer treatment especially for highly metastatic malignancies.However,the individual targeting s
【作 者】
：
Jinjin Chen Jianxun Ding Weiguo Xu Xiuli Zhuang Xuesi Chen 
【机 构】
：
Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of S
【出 处】
：
Fourth Symposium on Innovative Polymers for Controlled Deliv
【发表日期】
：
2016年11期
【关键词】
：
nanogel receptor-mediated targeting environment-mediated targeting intracellular 
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　　Targeted delivery of chemotherapeutic agents to desired lesion sites was a great challenge in clinical cancer treatment especially for highly metastatic malignancies.However,the individual targeting strategies toward overexpressed receptors or tumor microenvironments demonstrated great limitations owing to the off-target effect and tumor homogeneity.
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