Flurbiprofen is being considered for the treatment of Alzheimers disease because epidemiological data indicates that non-steroidal anti-inflammatory drugs are protective against neurodegeneration.
Tubulin-microtubule system,which involves crucially in the cell mitosis is an attractive target for the development of highly efficient anticancer drugs.[1] A series of cyclic iso-Combretastatin A-4(i
Microtubules are critical elements that are involved in a wide range of cellular processes,and thus,they have become an attractive target for many anticancer drugs.[1] A novel synthesized compound,12P
A series of scutellarein-O-amidoalkylbenzylamines were designed based on a multitarget-directed ligands strategy for the treatment of Alzheimers disease(AD).
A novel series of chalcone-O-alkylamines derivatives were designed,synthesized and tested as multi-target agents for the treatment of AD(Figure 1.).The results showed that most of these derivatives ex
Free fatty acid receptor 2(FFA2),also known as GPR43,is activated by short-chain fatty acids(SCFAs)which are mainly produced by the gut microbiota through the fermentation of undigested carbohydrates
Protein arginine methyltransferase 1(PRMT1)is an important member of PRMT subfamily,which catalyzes the transfer of a methyl group from the co-factor S-adenosyl methionine(SAM)onto a specific arginine