【摘 要】
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Objective: DNA methylation and histone modification are common epigenetic changes.The epigenetic change and CpG island methylator phenotype are closely related to poor prognosis of neuroblastoma (NB)
【机 构】
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Department of Pediatric Surgery,Shanghai Children's Medical Center,Shanghai Jiao Tong University,Sh
【出 处】
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22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会)
论文部分内容阅读
Objective: DNA methylation and histone modification are common epigenetic changes.The epigenetic change and CpG island methylator phenotype are closely related to poor prognosis of neuroblastoma (NB) in children.We have previously demonstrated that valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, exerts antitumor effects in an NB xenograft model.However, the underlying anti-tumor molecular mechanisms are largely unknown.In this study, the roles of HDAC in cell proliferation, cell cycle progression, gene expression patterns, and epigenome in neuroblastoma were investigated.
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