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  5. Molecular Modeling of Ligand Binding Domain in Glycine Receptor

Molecular Modeling of Ligand Binding Domain in Glycine Receptor

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：epwangke96
【摘 要】
：
Background: Glycine receptor (GlyR) is member of ligand-gated ion channels that are also referred to as the Cys-loop receptors due to conserved disulfide-bonded cysteines in the ligand binding domain
【作 者】
：
鲍劲霄 陈姣 郑珩 徐寒梅 
【机 构】
：
生命科学与技术学院,中国药科大学,南京,210009
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
homology modeling glycine receptor molecular dynamics ligand-gated ion channels 
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　　Background: Glycine receptor (GlyR) is member of ligand-gated ion channels that are also referred to as the Cys-loop receptors due to conserved disulfide-bonded cysteines in the ligand binding domain (LBD).This receptor mediate signaling across synapses of the central and peripheral nervous systems and is an interesting therapeutic target.The homology model of GlyR can be used in structure based design of noval ligands.
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