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Background: To detect the effect of hypoxia inducible factor mediated EMT in the mechanism of detrusor instability.Methods: A total of 49 patients with detrusor instability (DI) secondary to bladder outlet obstruction (BOO) were randomly choosed according to the urodynamic result as the study group.36 patients with BOO proved with detrusor instability (DS) by urodynamic as control group.