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Aim: To report on the changes over time in inflammatorymarkers following Roux-en-Y gastric bypass (RYGB) in patients of Chinese ethnicity.Materials and Methods: This prospective cohort study involved89patients who met the indications of bariatric surgery for obesity.Leptin,tumor necrosis factor α(TNF-α),adiponectin,C-reactive protein (CRP) and interleukin 6 (IL-6)were monitored from baseline to 12 months.Results: Body mass index (BMI) steadily decreased from 29.96 kg/m2 at baseline to 25.33 kg/m2 at 12 months following surgical intervention.CRP also decreased from 35.00 mg/dl at baseline to 20.00 mg/dl at 12 months.Leptin,adiponectin and IL-6 steadily decreased from their baseline values down to a nadir at six months,and rose thereafter up to 12 months,resulting in higher 12-months values thanks the baseline ones for adiponectin,but not for leptin and IL-6.A saw-teeth patternwas observed for TNF,with however the 12-month and all follow-up values remaining lower than the baseline values.