Objective:To evaluate clinical efficacy of terminal warm blood hypokalemia cardioplegia reperfusion for myocardial protection in the patients undergoing valve replacement.Methods:Forty patients undergoing elective valve replacement were randomly divided into two groups:experimental group (n =20) and control group (n =20).Before aortic unclamping,the experimental group was reperfused with warm blood hypokalemia cardioplegia plus creatine phosphate (10mmol/L),then reperfused with warm blood three minutes later; whereas the control group reperfused with warm blood only.The effect of myocardial protection of the two methods were evaluated.