【摘 要】
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GHRP-6 is a synthetic agonist of ghrelin receptor.GHRP-6 has similar physiological functions with ghrelin[1-2].In our previous study,ghrelin(i.c.v.)could induce analgesic effect through an interaction
【机 构】
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Department of Physiology,Medical College of Nanchang University,Bayi Road 461,Nanchang,Jiangxi,33000
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GHRP-6 is a synthetic agonist of ghrelin receptor.GHRP-6 has similar physiological functions with ghrelin[1-2].In our previous study,ghrelin(i.c.v.)could induce analgesic effect through an interaction with GHS-R1α and with the central opioid system in the acute pain in mice[3].Our previous research showed that GHRP-6 plays important roles in the control of pain through interaction with the opioid system in acute pain.However,very few studies show the effect of supraspinal GHRP-6 on antinociception induced by intracerebroventricular(i.c.v.)administration of morphine.In the present study,injection(i.c.v.)of GHRP-6(1,3,10 nmol/L)produced inhibition of systemic morphine(1 nmol/L,i.c.v.)analgesia in the tail withdrawal test.Furthermore,these anti-opioid activities of GHRP-6 were not blocked by pretreatment with the GHS-R1α selective antagonist [D-Lys3]-GHRP-6(100 nmol/L,i.c.v.).These results demonstrated that central GHRP-6 could inhibit the analgesia effect induced by intracerebroventricular(i.c.v.)administration of morphine.The anti-opioid effects of GHRP-6 dont interact with GHS-R1a.These findings may pave the way for a new strategy on investigating the interaction between ghrelin system and opioids on pain modulation.Keywords: GHRP-6,Growth hormone secretagogue receptor 1 alpha(GHS-R1a),Antinociception,Morphine,Tail withdrawal test.References [1] Bowers,C.Y.; Momany,F.A.; Reynolds,G.A.; Hong,A.Endocrinology 1984,114,1537-1545.[2]Delgado-Rubín,A.; Chowen,J.A.; Argente,J.; Frago,L.M.Eur.J.Neurosci.,2009,29,2115-2124.[3] Wei J,Zhi X,Wang XL,Zeng P,Zou T,Yang B,et al.Peptides 2013,43,76-82.
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