【摘 要】
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Hepatitis B virus (HBV) X antigen (HBx) plays an important role in the development of human hepatocellular carcinoma (HCC).We used an HBx transgenic mouse model to conduct genome-wide gene expression
【机 构】
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Division of Molecular and Genomic Medicine National Health Research Institute Taiwan
论文部分内容阅读
Hepatitis B virus (HBV) X antigen (HBx) plays an important role in the development of human hepatocellular carcinoma (HCC).We used an HBx transgenic mouse model to conduct genome-wide gene expression profiling at different stages of carcinogenesis and then systematically delineated the molecular events.Sub-network enrichment analysis in PathwayStudio suggested five cellular oncogenes (EDN1, BMP7, BMP4, SPIB and SRC) as common regulators for the differentially expressed genes based on cancer stage.
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