Protocadherin 10 Suppresses Tumorigenesis and Metastasis in Colorectal Cancer and Its Genetic Loss P

来源 :2013第六届世界癌症大会 | 被引量 : 0次 | 上传用户：aiming4636j

【摘要】

：

Chromosomal instability is the most common genetic abnormality in sporadic colorectal cancer (CRC).By loss of heterozygosity approach, we identified Protocadherin 10 (PCDH 10) gene at chromosome 4q28

【作者】

：

Tzu-Ming Jao Ming-Hong Tsai Wei-Ting Weng Hoi-Yah Lio Chia-Yun Chang Yen-Chun La Ya-Chien Yang

【机构】

：

Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National

【出处】

：

2013第六届世界癌症大会

【发表日期】

：

2013年12期

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　　Chromosomal instability is the most common genetic abnormality in sporadic colorectal cancer (CRC).By loss of heterozygosity approach, we identified Protocadherin 10 (PCDH 10) gene at chromosome 4q28 with a high frequency of allelic deletion in CRC.Importantly, the genetic alteration was significantly associated with presence of distant metastasis and poorer overall survival of patients.Meanwhile, PCDH10 gene expression was silenced or downregulated in 77.4% (41/53) of colorectal carcinomas compared with matched normal mucosas.

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Protocadherin 10 Suppresses Tumorigenesis and Metastasis in Colorectal Cancer and Its Genetic Loss P

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