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Orai3 is a store-operated Ca2+ channel specific for mammals.Previous studies showed that 2-APB, an agonist of Orai3 channel, can either prevent atrial fibrillation [1] or cause ventricular arrhythmia [2] in rabbits and rats, respectively.The aim of this study is to determine whether Orai3 mutation is a pathogenetic factor of atrial fibrillation.