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5. Distinct roles of DNMT1-dependent and-independent methylation patterns in the genome of mouse ES cel

Distinct roles of DNMT1-dependent and-independent methylation patterns in the genome of mouse ES cel

来源 :第四届国际肿瘤表观遗传学大会 | 被引量 : 0次 | 上传用户：cwy198783

【摘 要】

：

Background: DNA methylation patterns are critical for genome stability and gene transcription, and are initiated by de novo methylases DNMT3a/3b adding methyl groups to CG dinucleotides in the hypomet

【作 者】

：

Zhiguang Li Hongzheng Dai Beisi Xu Guangjing Zhu Teng Li Dustin E.Schones Zhibin Wang 

【机 构】

：

Laboratory of Human Environmental Epigenomes, Department of Environmental Health Sciences, Bloomberg

【出 处】

：

第四届国际肿瘤表观遗传学大会

【发表日期】

：

2014年8期

【关键词】

：

DNA methylation patterns genome stability gene transcription de novo methyltrans 

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Background: DNA methylation patterns are critical for genome stability and gene transcription, and are initiated by de novo methylases DNMT3a/3b adding methyl groups to CG dinucleotides in the hypomethylated genome of early embryos.

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