【摘 要】
：
Rare earth hydroxide(europium,Eu)nanoparticles were recently found to promote angiogenesis in human umbilical vein endothelial cells(HUVACs)after cell internalization.The exact mechanism of such biolo
【机 构】
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College of Environmental Science and Engineering,State Key Laboratory of Pollution Control and Resou
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Rare earth hydroxide(europium,Eu)nanoparticles were recently found to promote angiogenesis in human umbilical vein endothelial cells(HUVACs)after cell internalization.The exact mechanism of such biological effect was unclear.In this study,we set out to explore if additional types of rare earth based nanoparticles were capable of enhancing angiogenesis and further demonstrate the underlying mechanisms.In order to screen for pro-angiogenesis effect,we employed a high-throughput in vitro cell based screening strategy coupled with in vivo validation using vascular specific green fluorescent protein(GFP)reporter transgenic zebrafish.Although all four rare earth hydroxide nanoparticles,i.e.Eu(OH)3 rods(Eu rods),Eu(OH)3 spheres(Eu spheres),Tb(OH)3 rods(Tb rods),and Tb(OH)3 spheres(Tb spheres),showed pro-angiogenesis effect in vitro,only Eu rods and Eu spheres showed significant blood vessel recovery in vivo.It is also noted that ionic forms of europium(Eu(NO3)3 and Tb(NO3)3)were capable of exerting limited angiogenesis effect,but significantly less than its corresponding particulate form.Finally,by co-introducing the rare earth hydroxide nanoparticles with an ROS scavenger,catalase,we demonstrated indirectly that H2O2 is a key factor in the process of pro-angiogenesis by these rare earth hydroxide nanoparticles.
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