Inhibition of PI3KAkt signaling pathway activity induces downregulation of beta-cateninTCF4 pathway

来源 :Wnt信号、器官发育和干细胞国际学术大会(Wnt Signaling,Organogenesis,and Stem Ce | 被引量 : 0次 | 上传用户：eric_vl

【摘要】

：

　　Background Increasing evidence suggests that aberrant activation of PI3K/AKT and Wnt/β-catenin signaling pathways are involved in tumor development and pro

【作者】

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HAN Lei ZHANG An-ling SONG Yun-peng LIU zhe YUE xiao PU Pei-yu KANG Chun-sheng

【机构】

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TianjinMedicalUniversityGeneralHospitalandLaboratoryofNeuro-Oncoiogy,TianjinNeurologicalInstitute,Ti

【出处】

：

Wnt信号、器官发育和干细胞国际学术大会(Wnt Signaling,Organogenesis,and Stem Ce

【发表日期】

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2009年5期

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　　Background Increasing evidence suggests that aberrant activation of PI3K/AKT and Wnt/β-catenin signaling pathways are involved in tumor development and progression.Our earlier study on gene expression profile in human malignant gliomas by microarray found that some members of A KT and Wnt pathways were overexpressed.

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