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目的 Mitofusin-2gene(MFN2)encodesamitochondrialproteinwhichiscriticalformitochondrialfusionprocess.MFN2wasinitiallyidentifiedasahypertension-associatedgeneandimplicatedinthepathogenesisofmultiplecancertypes.However,rolesandunderlyingmechanismsofMFN2inlungadenocarcinomadevelopmentremaintobedetermined.