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Objective: The purpose was to compare folinic acid, 5-fluorouracil (5-FU), and irinotecan (mFOLFIRI;arm A) with folinic acid, 5-FU, and oxaliplatin (mFOLFOX7;arm B) as first-line treatments in patients (pts) with locally advanced or metastatic gastric adenocarcinoma in an open, randomized, phase Ⅱ, two-center study.