Genome-Wide Analysis of Human SNPs and cancer associated point mutations at m6A mRNA methylation pea

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户:epigeige
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Modification of mRNA by methylation of adenosine at the N6 position (m6A) is the most prevalent internal modification in mRNAs.The map of m6A RNA methylates with a ~100-nucleotide resolution have shown that m6A is widely distributed in more than 7,000 mRNA and 300 non-coding RNA (ncRNA) transcripts in human cells and the distribution is dynamic.
其他文献
Background: Finding candidates for cancer-associated genes are of great value for the prevention, diagnosis and treatment of cancer.Besides classic assays of molecular biology high-throughput technolo
Background: Genetic recombination is an important factor to change and shape genome and its relevant phenotypes.Gene transfer or reassortment and recombination in the nature happen quite frequent betw
Background: Against a declining trend of global HIV epidemic, HIV infection among men who have sex with men (MSM) was reported to be continuously increasing.We assess HIV burden representative by meas
Background: DNA methylation is one of the essential epigenetic mechanisms that are closely correlated with the prognosis progression in non-small cell lung cancer (NSCLC).Advances in computational app
Background: Irinotecan (SN38) and oxaliplatin-being part of FOLFIRI or XELOX/ FOLFOX treatment protocols, respectively-are commonly used in the treatment of colorectal cancer patients.However, the fre
Background: Due to the development of the high throughput technologies, large bioinformatics data is produced.How to select the meaningful information from the big bioinformatics data becomes very cru
Background: MiRNAs (mircroRNAs) are a class of small non-coding RNAs and play an important role in regulating a wide range of biological process, such as stem cell maintenance,development and metaboli
Background: According to genetics, similar set of genes may affect the similar phenotypes, and the similar phenotypes may be caused by a set of similar genes.So when we know the relevant genes of a ph
Background: Lynch syndrome (HNPCC) is an autosomal dominant genetic condition that has a high risk of cancers including ovarian cancer.Therefore,expound the relationship between genes and how those ge
Background: Wolfram syndrome(WS) is a rare, progressive, neurodegenerative disorder with an autosomal recessive pattern of inheritance, characterized by diabetes insipidus, diabetes mellitus, optic at