PI(3)P plays an essential role in multiple endocytic trafficking processes and autophagy.The class Ⅲ Vps34/Beclin 1/Atg14 PI(3)P kinase complex has been shown
Lysosomes are dynamic organelles involved in cellular clearance processes.It has been suggested that chronic impairment of cellular clearance may be a major
Mitochondria dysfunction is considered as a hallmark of multiple neurodegenerative diseases,such as Parkinsons disease (PD).Mutations in two PD related gene
BNIP3 is regulated by hypoxia through hypoxia-inducible factor 1(HIF-1), which binds to hypoxia response element (HRE) in the promoter of BNIP3 and activate
Autophagy is a highly conserved catabolic process in which cells degrade and recycle their own constituents through lysosomal degradation machinery.The phys
Schizophrenia (SCZ) is a complex disease that has been regarded as a neurodevelopmental,synaptic or epigenetic disorder.Here we provide evidence that neurod