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Objectives The aim of the present study was to analyse the association between levels of leptin and metabolic syndrome (MS) and the components of MS in Xinjiang Uygur Population.Methods A total of 781 individuals were selected from the cross-sectional study of MS from Hetian area in Xinjiang Uygur Autonomous Region, aged from 30 to 70 years, included 403 MS subjects and 378 non-MS controls, 249 men and 532 women.