论文部分内容阅读
IQGAP1 is a conserved multifunctional protein implicated in tumorigenesis by promoting cell proliferation,weakening cell adhesion,stimulating cell motility and invasion.The abnormal expression of IQGAP1 widely exists in many cancers,but the role of IQGAP1 modification in cancer development remains poorly understood.In this study,we found that the expression level of IQGAP1 and its SUMOylation level are both increased in colon cancer cells than normal epithelial cells.IQGAP1 is SUMOylated by the SUMO1 modification,and the Lys1445 residue is one of major sumoylation sites.In addition,we also confirmed that IQGAP1 SUMOylation could stabilize IQGAP1 by reducing protein ubiquitination.Moreover IQGAP1 SUMOylation is increased by epirubicin treatment.The SUMOylation of IQGAP1 promotes cell growth and cell migration of colon cancer cells.Our findings suggest that the SUMOylation of IQGAP1 plays important roles in the development of colon cancer.