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目的研究山茱萸有效成分莫诺苷对局灶性脑缺血再灌注大鼠皮质IL-1β的影响。方法用线栓法制备大鼠局灶性脑缺血再灌注模型,缺血30 min,再灌注72 h。以秋水仙碱为阳性对照药,采用酶联免疫吸附(ELISA)法检测大鼠脑皮层炎症因子IL-1β的变化。结果莫诺苷能显著增强大鼠抗炎能力。结论莫诺苷能通过增强大鼠皮层抗炎能力发挥神经保护作用。
Objective To study the effect of morroniside, an active ingredient of Cornus officinalis, on the cortical IL-1β in focal cerebral ischemia / reperfusion rats. Methods The model of focal cerebral ischemia-reperfusion in rats was established by thread occlusion method. The rats were subjected to ischemia 30 min and reperfusion 72 h. Colchicine was used as a positive control drug, and the changes of cortical inflammatory factor IL-1β in rats were detected by enzyme-linked immunosorbent assay (ELISA). Results Morroniside significantly increased anti-inflammatory ability in rats. Conclusion Morroniside can exert neuroprotective effect by enhancing the anti-inflammatory ability of cortex in rats.